Figure 1b. Screening mammograms in a 63-year-old woman demonstrate breasts composed mostly of fat and were prospectively interpreted as negative. Cancer was detected in the right breast at the 6-o’clock position on the next scheduled screening mammogram 14 months later. (a, b) At the 6-o’clock position in the right breast are branching pleomorphic calcifications (arrow). Reasons for possible miss include the location of the lesion at the edge of the breast on the mediolateral oblique (MLO) view and distracting lesions elsewhere in the breasts. (c) Photographic enlargement of the standard craniocaudal (CC) view demonstrates morphology of the calcifications as branching and pleomorphic. (d) CAD images of the digitized mammograms show marks generated by the computer algorithm. The calcifications are marked with a triangle on both the CC and MLO views. There also is one false-positive CAD mark on benign calcifications in each of the four views.