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Figure 4. Graph shows time dependence of (SIpost - SIpre) in the ischemic leg and the normal leg at different times after ischemia induction (mean ± SEM). Data were obtained in the ischemic leg 1 day ({blacklozenge}), 7 days ({blacksquare}), and 14 days ({blacktriangleup}) after ischemia induction and in the contralateral nonischemic leg ({bullet}). {ddagger} = 1 day was significantly different from the control (unpaired t test; P < .05). * = 1, 7, and 14 days were significantly different from the control (unpaired t test, P < .05). The curves obtained in the affected areas showed rapid enhancement; this was followed by a plateau after approximately 60 seconds.