Figure 14a. Transgenic mouse model of AD (tg2576). (a) Section from entorhinal cortex demonstrates in vivo labeling of amyloid plaques. Fluorescent labeling of plaques is seen after intravenous injection of (trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene, or BSB, an amyloid ß binding agent that crosses the blood-brain barrier. (Original magnification, x400.) (b) The same section was also immunostained with amyloid ß-specific antiserum 2332, as demonstrated in this light microscopy image. (Original magnification, x400.) (c) Digital overlay of a and b reveals high specificity of BSB plaque labeling. (Original magnification, x400.) (Adapted and reprinted, with permission, from reference 100.)