Figure 3d: Macroadenoma with hard consistency in 32-year-old woman. (a) Coronal spin-echo T2-weighted MR image (3000/110) shows large inhomogeneous hyper- and isointense mass (arrows) with respect to white matter. (b) Coronal DW single-shot spin-echo echo-planar MR image (5000/101) with diffusion gradient in three principal orthogonal axes and b values of 0 and 1000 sec/mm2 shows hypointense mass (arrows) with respect to normal white matter. (c) ADC map shows mass (arrows) with marked increase of diffusion coefficient as compared with that of brain parenchyma, (1.349 ± 0.099) x 10–3 mm2/sec. (d) Specimen at histologic examination shows mass characterized by areas with moderate cellularity (in blue) and little fibrosis (in red) as shown at bottom and areas with abundant fibrous stroma and low cellularity as seen at top. (Sirius red stain; original magnification, x20.)