View larger version (191K)

Figure 2c: (a) Transverse thin-section (1-mm-thick) CT scan in a 26-year-old man with mild CF, as scored by both radiologists. Abnormalities include mild bronchiectasis (straight solid arrow), peribronchial thickening (open arrow), and peripheral mucus plugging (curved arrow). (b) Corresponding exercise graph shows O₂ uptake (VO2) () and workload; there is mild exercise impairment, with a peak O₂ uptake of 3.2 L/min and a peak workload of 227 W. (c) Transverse thin-section (1-mm-thick) CT scan in a 28-year-old woman with moderate CF, as scored by both radiologists. Abnormalities include moderate changes of bronchiectasis (straight arrows) and subsegmental collapse (curved arrow); note anterior deviation of the horizontal fissure. (d) Corresponding exercise graph shows O₂ uptake () and workload; there is moderate exercise impairment, with a peak O₂ uptake of 1.4 L/min and a peak workload of 124 W. (e) Transverse thin-section (1-mm-thick) CT scan in a 23-year-old man with severe CF, as scored by both radiologists. Thin-section CT abnormalities include severe bronchiectasis (curved arrow), severe peribronchial thickening (open arrow), and large bullae (straight solid arrow). (f) Corresponding exercise graph shows O₂ uptake () and workload; there is severe exercise impairment, with a peak O₂ uptake of 0.86 L/min and a peak workload of 72 W.