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Radiology, Vol 116, 133-136, Copyright © 1975 by Radiological Society of North America

ARTICLES

Familial neuroblastoma presenting as multiple tumors

FF Roberts and KR Lee

Multiple primary tumors are a common mode of presentation in familial neuroblastoma but must be differentiated from metastatic disease. The cases of 2 siblings with multiple neuroblastomas are presented and 44 additional cases of neuroblastoma reviewed. It was found that primary tumors localize to the posterior mediastinum, the adrenals, and the paravertebral ganglia whereas metastatic disease is found in the anterior and middle mediastinum, bones and para-aortic nodes. Based on these observations, the diagnosis of multiple primary tumors can be made and should lead to early consideration of familial neuroblastoma.


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G. J. Lonergan, C. M. Schwab, E. S. Suarez, and C. L. Carlson
From the Archives of the AFIP : Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma: Radiologic-Pathologic Correlation
RadioGraphics, July 1, 2002; 22(4): 911 - 934.
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