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Radiology, Vol 119, 459-461, Copyright © 1976 by Radiological Society of North America

ARTICLES

Fast neutron and x-ray induced single strand DNA breaks in cultured mammalian cells

AJ Moss Jr, ML Baker, RM Prior, EA Erichsen, WA Nagle and GV Dalrymple

The relative biologic effectiveness (RBE) of fast neutrons in the production of single strand DNA breaks is 1.6 as compared to that of 250 kVp x rays. Monolayers of L-929 cells were treated with dinitrophenol during irradiation to prevent the DNA strands from rejoining; the extent of DNA damage was measured by the alkaline sucrose sedimentation method. The RBE for DNA damage is essentially the same as the RBE measured by cell survival methods.




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