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Radiology, Vol 119, 715-720, Copyright © 1976 by Radiological Society of North America

ARTICLES

Mammalian cell survival response following irradiation with 4 MeV X rays or accelerated helium ions combined with hyperthermia

EW Gerner, JT Leith and ML Boone

The effects of hyperthermia on Chinese hamster ovary cell radioresponse were studied using either 4 MeV x rays or accelerated helium ions. Both pre-and postirradiation hyperthermic doses act to decrease the slope of the x-irradiation survival curve in a temperature-dependent manner, while the extrapolation number does not change appreciably. Pre- irradiation hyperthermic treatment has only a slightly greater dose- modifying effect than similar postirradiation hyperthermia. For cells irradiated with helium, pre-irradiation at 43 degrees C (1 hr.) changes the radiation survival curve slope and also the extrapolation number, implying that hyperthermia may act more readily to enhance lethal x-ray damage than lethal helium damage, while having a similar effect on the accumulation of sublethal damage for both of these radiations.




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