Radiology, Vol 120, 53-55, Copyright © 1976 by Radiological Society of North America
A new, simple test for thrombogenicity
K Amplatz
A simple technique is described to test thrombogenicity in dogs. Materials
to be tested are introduced percutaneously into the femoral arteries of
dogs in the form of a No. 5 catheter which is advanced to the aortic
bifurcation. Another catheter can be introduced into the contralateral
femoral artery in order to test two different materials in the same animal
at the same time. After the catheter has been exposed to arterial blood for
one hour, it is removed with a large-bore retrieval system, and all fibrin
deposits are collected in a plastic basket. Significant thrombus formation
was almost uniformly present in over 100 control studies. The technique has
the advantage of being relatively noninvasive, allowing the testing of
several materials in the same animal and yielding consistent results.
