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Radiology, Vol 121, 105-109, Copyright © 1976 by Radiological Society of North America

ARTICLES

Changes in cerebral blood volume and vascular mean transit time during induced cerebral seizures

MH Gado, ME Phelps, EJ Hoffman and ME Raichle

The relationship of the mean transit time of the vascular indicator C15O-labeled hemoglobin (tco) and the cerebral blood volume (CBV) as measured by stimulated x-ray fluorescence, to the mean arterial blood pressure (MABP) was examined in rhesus monkeys before and during experiment cerebral seizures. The results demonstrate a marked increase in CBV and a decrease in tco. A substantial portion of these changes is the passive accompaniment of the associated increase in MABP.




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