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Radiology, Vol 121, 479-482, Copyright © 1976 by Radiological Society of North America

ARTICLES

In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation

RR Weichselbaum, J Epstein and JB Little

Four diploid cell strains were derived from skin biopsies from patients exhibiting unusually sensitive or resistant clinical responses to ionizing radiation during radiotherapy. The in vitro x-ray survival curve parameters for these strains were determined and compared with those of two normal human skin fibroblast strains. No systematic correlation could be demonstrated between these single dose survival parameters in vitro, and the clinical radiation response in vivo of the normal tissue or the tumor.


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