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Radiology, Vol 122, 239-242, Copyright © 1977 by Radiological Society of North America

ARTICLES

Dose effect relationship for epilation and late effects on spinal cord in rats exposed to gamma rays

K Masuda, BO Reid and HR Withers

The response of rat spinal cords (T7-T12) exposed to single and multifractionated gamma-ray exposures revealed no significant differences between the threshold doses for 2 fractions given with a 24- hr. interval and 2 fractions given with a 15-day interval. The latent period for spinal cord damage was about 190 days when the incidence of paralysis was high; it was less than this in animals with a lower probability of paralysis. There was a marked sparing effect from dose fractionation: the initial part of a Strandqvist type of isoeffect curve had a slope of 0.44 for doses causing paralysis in 50% of the animals, and 0.36 for "threshold" doses. The level of epilation was not useful for predicting spinal cord damage.




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