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Radiology, Vol 124, 837-838, Copyright © 1977 by Radiological Society of North America

ARTICLES

Distribution of 99mTc-1-thioglucose in rats: effect of administration route on pancreatic specificity

VR Risch, T Honda, ND Heindel, JL Emrich and LW Brady

Tissue distribution of 99mTc-1-thioglucose was studied in inbred albino Fisher rats. High levels of radioactivity were observed in the kidney with concurrent low pancreatic levels and pancreas/liver ratios of 0.4 following intravenous administration of the agent. High pancreatic concentration were observed with pancreas/liver ratios of 4.0 after intraperitoneal administrations. Future studies on pancreatic radiopharmaceuticals should avoid production of artificially high pancreatic values by intraperitoneal injection.




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RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1977 by the Radiological Society of North America.