Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peters, L. J.
Right arrow Articles by Patt, Y. Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peters, L. J.
Right arrow Articles by Patt, Y. Z.

Radiology, Vol 126, 499-505, Copyright © 1978 by Radiological Society of North America

ARTICLES

Enhancement of lung colony-forming efficiency by local thoracic irradiation: interpretation of labeled cell studies

LJ Peters, K Mason, WH McBride and YZ Patt

The dynamics of 125IUdR-labeled tumor cell retention in the lungs have been compared with the efficiency of lung colony formation over a wide range of inoculum sizes in normal mice and in mice pretreated with 1000 rads local thoracic irradiation (LTI). These studies indicate that the increase in lung colony yield after LTI cannot be ascribed to improved intravascular trapping or interstitial lodgement of tumor cells. Hypotheses purporting that active specific or nonspecific host defense might be impaired by LTI were reassessed but rejected in favor of the idea that radiation-induced alterations in the physiological mocroenvironment of the lungs improve an intrinsically poor survival capability of intravenously disseminated tumor cells.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1978 by the Radiological Society of North America.