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Radiology, Vol 128, 499-501, Copyright © 1978 by Radiological Society of North America

ARTICLES

Differential effects of sodium meglumine calcium metrizoate on the inotropic state of normal and ischemic myocardium

AV Als, JR Serur, PJ LaRaia, NC Miner and S Paulin

Sodium meglumine calcium metrizoate was injected into isolated blood- perfused canine hearts to evaluate the effect of contrast agents containing calcium on normal and ischemic myocardium. Under normal perfusion pressure and mild ischemia, this contrast agent produced a positive inotropic effect, but during profound ischemia, this positive effect was followed by a period of myocardial depression. These findings indicate that the addition of an inotropic agent to contrast medium can produce a paradoxical depressant effect which can be deleterious to the ischemic myocardium.




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