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Radiology, Vol 128, 793-794, Copyright © 1978 by Radiological Society of North America

ARTICLES

Experimental and clinical trials of new 99mTc-labeled hepatobiliary agents

BW Wistow, GM Gagne, RW Henderson, JG McAfee, RC Hall and ZD Grossman

Several new derivatives of lidocaine were synthesized and used to examine the intra- and extrahepatic bile ducts and gallbladder. Diisopropyl-IDA exhibited approximately twice the bile concentration of 131I-rose bengal during the first hour after injection. P-butyl-IDA also concentrates moderately well in the bile and has the added advantage of very low excretion into the urine (2%). It seems more effective than the other IDA derivatives at high bilirubin levels.




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