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Radiology, Vol 130, 789-791, Copyright © 1979 by Radiological Society of North America

ARTICLES

The effect of whole-body irradiation on skeletal growth in rhesus monkeys

P Sonneveld and DW van Bekkum

Late effects of single whole-body doses of 400--500 and 750--900 rads on skeletal growth in 32 rhesus monkeys were studied. Findings indicated growth inhibition strongly related to dose and age at irradiation. Doses of 750--900 rads before the age of 40 months resulted in significantly greater growth inhibition (11%) than doses given during or shortly after adolescence (p less than 0.005). Doses of less than 750 rads were not significant. In view of the close similarity between monkeys and man, irradiation of children at doses greater than 750 rads may carry a strong risk of subsequent growth retardation.


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D. W. van Bekkum
Effectiveness and risks of total body irradiation for conditioning in the treatment of autoimmune disease with autologous bone marrow transplantation
Rheumatology, August 1, 1999; 38(8): 757 - 761.
[Abstract] [Full Text] [PDF]


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