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Radiology, Vol 131, 759-762, Copyright © 1979 by Radiological Society of North America

ARTICLES

Comparison of the protective action of glutathione and cysteamine on radiation-induced mitotic delay in cultured S-5 cells

S Kawasaki, M Kobayashi, H Hashimoto and T Nakanishi

The protective effect of glutathione (GSH) and cysteamine (MEA) on radiation-induced mitotic delay in cultured mammalian L-5 cells was studied. Cells treated with 20 mM of GSH during irradiation with 2 Gy (200 rad) showed faster recovery of the mitotic index than control cells irradiated without chemical treatment; however, GSH had no effect on mitotic delay time. Inhibition of mitosis was observed with 80, 100, and 120 mM of GSH. Cells treated with 5 mM of MEA during irradiation also showed faster recovery of the mitotic index than the controls, but in addition the delay time was shortened. Progression of G2-phase cells treated with 5-fluorouracil to mitosis after irradiation was protected by MEA but not by GSH. Progression of S-phase cells labeled with 3H- thymidine to mitosis was accelerated by both agents during irradiation.




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