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Radiology, Vol 131, 791-792, Copyright © 1979 by Radiological Society of North America

ARTICLES

The effect of penicillamine on radiation-induced pulmonary lethality in mice

B Percarpio and JJ Fischer

The collagen inhibitor D-penicillamine was evaluated as a potential radiation reaction preventive agent by studying its effect on deaths attributed to pulmonary damage in mice. Long-term administration of D- penicillamine at a rate of 100 mg/kg/day had no significant effect on the LD50/160 in mice following pulmonary irradiation.




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