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Radiology, Vol 132, 171-174, Copyright © 1979 by Radiological Society of North America

ARTICLES

Tumor sterilization following high-dose pre-operative irradiation for advanced cancer of the larynx or pyriform sinus

JA Stryker, CK Chung, JA Clement, GH Conner, M Strauss, AB Abt and DE Velkley

Twenty-two patients with advanced laryngeal cancer and 5 with advanced pyriform sinus cancer were given 51 Gy (5,100 rad) followed by surgical resection. In 10 (45%) of patients with laryngeal cancer, no tumor was found at the primary site pathologically; 15 (68%) had negative neck specimens. All of those with pyriform sinus cancer had positive specimens. Eighteen patients with laryngeal cancer are free of disease. In contrast, only 1 with pyriform sinus cancer is free of disease; 1 has had a local recurrence and 3 have had metastases. The data suggest that 51 Gy (5,100 rad) are insufficient to sterilize pyriform sinus cancer; higher doses together with adjuvant chemotherapy are needed.




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