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Radiology, Vol 132, 341-342, Copyright © 1979 by Radiological Society of North America


ARTICLES

Inhibition of platelet aggregation by contrast media

U Gafter, D Creter, D Zevin, R Catz and M Djaldetti

The effect of 30% Urografin on platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, and arachidonic acid was examined. In vivo and in vitro experiments in 10 nondiabetic subjects and in vitro experiments in 7 diabetic-uremic patients showed a statistically significant decrease in platelet aggregation 20 minutes after in vitro incubation or in vivo infusion with Urografin. Urografin concentration was about 2.4-2.5%. The possibility of bleeding induced by contrast media and the connection with acute renal failure in diabetic-uremic patients are discussed.





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