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Radiology, Vol 133, 601-603, Copyright © 1979 by Radiological Society of North America

ARTICLES

Hemophilia and the female: considerations for the radiologist

RM Heller, JS Roloff, SG Kirchner and E Engel

Hemophilia A and B are commonly considered male diseases because of their X-linked recessive inheritance, but clinical hemophilia is occasionally seen in females. This may represent an extreme example of the Lyon hypothesis in which a heterozygous female has only the one X chromosome bearing the aberrant gene in the active state.




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