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Radiology, Vol 133, 731-735, Copyright © 1979 by Radiological Society of North America

ARTICLES

Regression of Hodgkin disease in the mediastinum: a mathematical model

JV Fayos, WC Chen, YH Kim and ML Votaw

Twenty-seven patients with mediastinal Hodgkin disease were teated either by radiation therapy or chemotherapy. The rates of tumor regression were measured and were fitted into a three-parameter Gompertzian model. Tumor regression was more pronounced and prompt in patients treated with radiotherapy. The Gompertzian model matched the radiation therapy data closely in the first 90 days after initiation of therapy in cases of approximately equal tumor size.




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Copyright © 1979 by the Radiological Society of North America.