Radiology, Vol 136, 585-592, Copyright © 1980 by Radiological Society of North America
The effect of diet and fasting on gallbladder opacification during oral cholecystography in dogs as measured by computed tomography
GT Fon, TB Hunter, RN Berk and MP Capp
To determine the influence of diet and fasting on gallbladder opacification
during oral cholecystography, 10 dogs were studied in a blind, random
fashion, giving single or two consecutive doses of iopanoic acid, sodium
tyropanoate, or sodium ipodate while the animals were fasting, on a normal
diet, or on a low-fat diet. Gallbladder density was determined by CT to
eliminate the bias created by subjective interpretation of radiographs. For
maximum, first-dose gallbladder opacification during clinical
cholecystography, iopanoic acid should be given with a meal and sodium
ipodate while the patient is fasting; diet makes no difference with sodium
tyropanoate. For maximum opacification with two consecutive doses, iopanoic
acid may be given with a meal or during fasting, while sodium ipodate and
sodium tyropanoate should be administered during fasting.
