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Radiology, Vol 136, 763-766, Copyright © 1980 by Radiological Society of North America

ARTICLES

Evaluation of high-dose vitamin E as a radioprotective agent

RA Rostock, JA Stryker and AB Abt

Sixty male Spraque Dawley rats were randomly divided into six equal groups and given 0, 1500 rads (15 Gy), and 2000 rads (20 GY) whole thoracic irradiation from a cobalt-60 source via an anterior portal. Thirty animals received a 2.5% vitamin E diet for two weeks prior to irradiation and, in addition, each was given a single intraperitoneal injection of water-soluble alpha T (150 mg) four hours prior to irradiation. Serum vitamin E levels were 646 +/- 76 microgram/ml for vitamin E groups and 6.0 +/- 2.4 microgram/ml for controls. Comparison of the 180-day survival curves and histologic studies performed on the lungs and hearts of the surviving animals showed no statistically significant differences between the vitamin E and control group.


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