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Radiology, Vol 138, 207-209, Copyright © 1981 by Radiological Society of North America

ARTICLES

Detection of gastrointestinal blood loss with 99mTc-labeled, heat- treated red blood cells

P Som, ZH Oster, HL Atkins, AG Goldman, DF Sacker, WH Harold, RG Fairchild, P Richards and AB Brill

Studies in dogs showed that heat-treated 99mTc-labeled red blood cells (HT/RBC) afford a highly sensitive means of detecting gastrointestinal bleeding as low as 0.12 ml/min., which could not be seen with unheated 99mTc-RBC, 99mTc-sulfur colloid, or 99mTc-DTPA. In addition, as the right upper quadrant and epigastrium remained free of activity, only one fifth to one tenth of the dose of 99mTc was needed. The safety of HT/RBC in humans has been documented, and the experiments in dogs suggest that it may have advantages over other agents in detecting gastrointestinal bleeding.




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