Radiology, Vol 139, 479-483, Copyright © 1981 by Radiological Society of North America
Irradiation in the treatment of Hodgkin disease: a follow-up report
YH Kim and JV Fayos
From 1971 through 1976, 167 patients with Hodgkin disease received
radiation therapy. In 132, staging was determined upon laparotomy; the
others had clinical staging. Most patients with stage I or II disease
received either mantle or para-aortic-iliac irradiation, while the others
received more extensive irradiation with or without chemotherapy. Overall
five-year actuarial survival rate was 87%; Stage I, 97%; Stage II, 85%; and
Stage III, 82%. Fifty-nine of the 167 patients had relapse of disease, and
most relapses were seen in Stage II, located in the nodal sites on the
opposite side of the diaphragm. Overall five-year relapse-free survival was
58%; Stage I, 94%; Stage II, 43%; and Stage III, 59%. Survival after the
first relapse was 69%. Based on their results, the authors feel that Stage
I disease of supradiaphragmatic presentation can be treated effectively
with mantle field irradiation alone. In treating Stage II disease, mantle
field irradiation alone was not optimal, and the authors recommend subtotal
nodal irradiation.
