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Radiology, Vol 139, 485-487, Copyright © 1981 by Radiological Society of North America

ARTICLES

In vitro radiosensitivity of human leukemia cell lines

RR Weichselbaum, JS Greenberger, A Schmidt, A Karpas, WC Moloney and JB Little

The in vitro radiobiologic survival values (n, D0) of four tumor lines derived from human hematopoietic tumors were studied. These cell lines were HL50 (n = 1.3, D0 = 117 rad[1.17 Gy]), promyelocytic leukemia; K562 (n = 1.4, D0 = 165 rad[1.65 Gy]), erythroleukemia; 45 (n = 1.1, D0 = 147 rad[1.47 Gy]), acute lymphocyte leukemia; and 176 (n = 4.0, D0 = 76 rad[0.76 Gy]), acute monomyelogenous leukemia. More cell lines must be examined before the exact relationship between in vitro radiosensitivity and clinical radiocurability is firmly established.


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