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Radiology, Vol 143, 317-320, Copyright © 1982 by Radiological Society of North America

ARTICLES

Gastrointestinal response to minute doses of glucagon

RE Miller, SM Chernish, GF Greenman, DD Maglinte, BD Rosenak and RL Brunelle

Small doses of glucagon are effective when performing a biphasic gastrointestinal (GI) examination. The authors conducted a controlled double-blind crossover study to determine the optimum and smallest effective doses and the onset and duration of drug action. Fifteen men received a placebo and 0.025, 0.05, 0.1, and 0.2 mg of glucagon intravenously. Hypotonicity of the stomach, duodenum, and small bowel was adequate with 0.1 mg of glucagon. Low-dose glucagon makes the biphasic upper GI examination short and practical. There is no need to delay the second phase of the examination or the small-bowel follow- through.


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