Radiology, Vol 151, 305-309, Copyright © 1984 by Radiological Society of North America
Vasoconstrictive effects of prostaglandin F2 alpha angiography on colonic lesions
Y Yuasa, E Kohda, K Ido, K Kodera, Y Narimatsu, Y Isobe and K Hiramatsu
In a study of 54 patients with a variety of lesions, prostaglandin F2 alpha
pharmacoangiography produced vasoconstrictive effects in both neoplastic
and inflammatory lesions of the colon. These effects occurred only at the
affected sites and their immediate vicinity. Vasoconstriction seemed to
correlate directly with the vascularity of the lesion, rather than with
pathogenesis. Less marked vasoconstriction was seen in renal lesions. No
vasoconstrictive effects were recognized in liver, soft tissue, or bone
tumors. Thus prostaglandin F2 alpha acts as a vasodilator in normal human
colonic vessels, while it acts as a vasoconstrictor in colonic lesions. The
potential use of prostaglandin F2 alpha in the control of bleeding colonic
lesions is also discussed.
