Radiology, Vol 152, 203-204, Copyright © 1984 by Radiological Society of North America
Contrast media induced fibrillation: comparison of Angiovist 370 and Renografin 76. Work in progress
TW Morris, LG Sahler, LK Whynot and K Hayakawa
Angiovist 370, a new formulation of meglumine/sodium diatrizoate, is being
marketed for coronary arteriography. Angiovist 370 contains no significant
calcium chelator additives, but according to manufacturer specifications
may have a pH as low as 6.0. The contact times required to produce
ventricular fibrillation with Angiovist 370 and with Renografin 76 were
compared using a canine right coronary arteriography model. The
fibrillation contact time was 32.2% longer for the Angiovist 370 than for
the Renografin 76. The lower pH therefore does not appear to increase the
risk of contrast media induced fibrillation. The increased contact time and
safety factor with the Angiovist 370 is most likely related to the absence
of calcium chelators in the formulation.
