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Radiology, Vol 152, 615-619, Copyright © 1984 by Radiological Society of North America

ARTICLES

Nephrotoxicity of contrast media assessed by occlusion arteriography

G Lund, J Rysavy, E Salomonowitz, A Cragg, Z Vlodaver, W Bendell, W Castaneda- Zuniga and K Amplatz

The authors describe an experimental model for the study of nephrotoxicity induced by contrast media, based on a standardized injection combined with occlusion of the renal artery so as to expose the kidney to a high concentration of contrast medium for ten minutes. Iopamidol, ioxaglate, and both isosmolar and hyperosmolar saline were well tolerated, but diatrizoate caused marked radiological and pathological changes. This model may be helpful in studies of the mechanisms underlying contrast medium nephrotoxicity and evaluating differences in toxicity between contrast agents.


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