Radiology, Vol 153, 195-201, Copyright © 1984 by Radiological Society of North America

ARTICLES

Fatty infiltration of the liver: demonstration by proton spectroscopic imaging. Preliminary observations

JK Lee, WT Dixon, D Ling, RG Levitt and WA Murphy Jr

Two normal volunteers and three patients with CT evidence of fatty infiltration of the liver (two nonuniform, one diffuse) were studied to determine whether magnetic resonance imaging using a pulse sequence designed to differentiate fat and water could be used to detect fatty infiltration of the liver in human beings. The magnetic resonance technique used a modified spin echo technique (simple proton spectroscopic imaging) that was designed specifically to exploit the difference in the rate of precession between the protons in a water molecule and the protons in a fatty acid molecule. Images were obtained using in-phase and opposed techniques and were added or subtracted in order to obtain pure water and pure fat images. Quantitative data showed that fatty liver can be separated from normal liver using the spin echo technique, and that the opposed image of the proton spectroscopic technique is more sensitive to small changes in hepatic fatty content than in-phase images with any echo time.

This article has been cited by other articles:

				C. Maffeis, R. Manfredi, M. Trombetta, S. Sordelli, M. Storti, T. Benuzzi, and R. C. Bonadonna Insulin Sensitivity Is Correlated with Subcutaneous but Not Visceral Body Fat in Overweight and Obese Prepubertal Children J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2122 - 2128. [Abstract] [Full Text] [PDF]

				C. G. Lall, A. M. Aisen, N. Bansal, and K. Sandrasegaran Nonalcoholic Fatty Liver Disease Am. J. Roentgenol., April 1, 2008; 190(4): 993 - 1002. [Abstract] [Full Text] [PDF]

				H. Raeder, I. S. Haldorsen, L. Ersland, R. Gruner, T. Taxt, O. Sovik, A. Molven, and P. R. Njolstad Pancreatic Lipomatosis Is a Structural Marker in Nondiabetic Children With Mutations in Carboxyl-Ester Lipase Diabetes, February 1, 2007; 56(2): 444 - 449. [Abstract] [Full Text] [PDF]

				H. K. Hussain, T. L. Chenevert, F. J. Londy, V. Gulani, S. D. Swanson, B. J. McKenna, H. D. Appelman, S. Adusumilli, J. K. Greenson, and H. S. Conjeevaram Hepatic Fat Fraction: MR Imaging for Quantitative Measurement and Display--Early Experience Radiology, December 1, 2005; 237(3): 1048 - 1055. [Abstract] [Full Text] [PDF]

				J. Song, K. A. da Costa, L. M. Fischer, M. Kohlmeier, L. Kwock, S. Wang, and S. H. Zeisel Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD) FASEB J, August 1, 2005; 19(10): 1266 - 1271. [Abstract] [Full Text] [PDF]

				A. S. Fulcher, R. A. Szucs, M. J. Bassignani, and A. Marcos Right Lobe Living Donor Liver Transplantation: Preoperative Evaluation of the Donor with MR Imaging Am. J. Roentgenol., June 1, 2001; 176(6): 1483 - 1491. [Abstract] [Full Text] [PDF]

				M. Maas, P. F. Dijkstra, and E. M. Akkerman Uniform Fat Suppression in Hands and Feet through the Use of Two-Point Dixon Chemical Shift MR Imaging Radiology, January 1, 1999; 210(1): 189 - 193. [Abstract] [Full Text]

				J.-Z. Wang, R. S. Mezrich, and J. B. Kostis The Use of Magnetic Resonance Imaging in the Study of Endema Angiology, May 1, 1991; 42(5): 358 - 364. [Abstract] [PDF]

				P. Bottomley Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy Science, August 23, 1985; 229(4715): 769 - 772. [Abstract] [PDF]