Radiology, Vol 156, 783-786, Copyright © 1985 by Radiological Society of North America
Gastric ulcer localization by direct in vivo labeling of sucralfate. Work in progress
A Pera, RH Seevers, K Meyer, C Hall, C Bekerman, TM Anderson, H Katzen, L Laakso and SM Pinsky
We developed and evaluated a new procedure for imaging gastric ulcer
disease with technetium 99m-labeled sucralfate. The new method employs
direct in vivo labeling of sucralfate instead of in vitro labeling using
human serum albumin, as previously reported in the literature. Tests using
hydrochloric acid and a rabbit ulcer model showed the efficacy of the
direct in vivo labeling technique and the ability of the tagged material to
bind to ulcers, respectively. In 26 studies using humans with sucralfate
labeled directly in vivo, 15 gave true- negative results and 11 gave
true-positive results. Of 14 studies using humans with in vitro labeled
sucralfate, three gave true-negative results, three gave true-positive
results, and the results of eight were either false-negative or could not
be interpreted because of high levels of activity remaining in the stomach.
We suggest that the direct in vivo labeling method significantly improves
the sucralfate gastric ulcer imaging technique.
