Radiology, Vol 159, 477-483, Copyright © 1986 by Radiological Society of North America
Glioblastoma: catheter techniques for isolated chemotherapy perfusion
JL Doppman, RL Dedrick, DR Shook, RJ Lutz, SR Goldstein, JB Blacklock, JW Boretos, RH Paul, HA Austin 3d and RL Bowman
Techniques have been developed for isolated perfusion of chemotherapeutic
agents in patients with glioblastoma. Three catheters that facilitate
crossing the carotid siphon have been developed; two are based on an
everting or toposcopic principle, and one uses microjets for deflectability
and improved mixing. Blood from the ipsilateral jugular vein is aspirated
at high volumes (300 ml/min) for extracorporeal circulation through an
adsorption column (for recovery of carmustine) or dialysers (for recovery
of cisplatin). Preliminary experience in 10 patients suggests that high
doses of chemotherapeutic agent can be administered using these catheters,
with reduced retinal and systemic toxicity.
