Radiology, Vol 166, 747-752, Copyright © 1988 by Radiological Society of North America
Colorectal tumors: scintigraphy with In-111 anti-CEA monoclonal antibody and correlation with surgical, histopathologic, and immunohistochemical findings
HH Abdel-Nabi, AN Schwartz, G Goldfogel, JA Ortman-Nabi, DM Matsuoka, MW Unger and DG Wechter
Department of Nuclear Medicine, State University of New York, Buffalo.
A prospective clinical study of 17 patients with a histologic diagnosis of
colorectal carcinoma proved at colonoscopy and surgery was performed with
indium-111 anticarcinoembryonic-antigen (CEA) monoclonal antibody (MoAb),
ZCE-025. MoAb scanning depicted nine of 16 primary colorectal carcinomas on
planar scintigrams (true-positive findings = 56%) and ten of 16 lesions on
single-photon emission computed tomography (SPECT) scans (true-positive
findings = 62%). Liver metastases were detected in three of three patients,
and lymph node metastases were detected in one of four patients.
Immunohistochemical examination for CEA in resected colorectal cancer
tissues demonstrated a positive correlation between MoAb imaging of primary
lesions and cytoplasmic-stromal intracellular CEA distribution. There was
no correlation between CEA serum levels and lesion detectability with MoAb
scanning.
