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Radiology, Vol 166, 835-838, Copyright © 1988 by Radiological Society of North America

ARTICLES

MR imaging of rat brain glioma: Gd-DTPA versus Gd-DOTA

VM Runge, S Jacobson, ML Wood, D Kaufman and LS Adelman
Department of Radiology, New England Medical Center Hospitals, Boston, MA 02111.

The enhancement properties of gadolinium diethylenetriaminepentaacetic acid (DTPA) and gadolinium tetraazacyclododecanetetraacetic acid (DOTA) were compared using a rat glioma model. In vitro analysis included the calculation of T1 relaxivity and determination of characteristic curves. Enhancement of the intracerebral glioma was studied in 23 rats approximately 2 weeks after glioma implantation with Gd-DTPA in 12 rats and Gd-DOTA in 11 rats. Six rats were also studied 1 week after implantation. Gd-DTPA exhibited a slightly greater T1 relaxivity in vitro than Gd-DOTA. Enhancement of the glioma was also greater with Gd- DTPA than with Gd-DOTA (P less than .05).




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