Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sijens, P. E.
Right arrow Articles by Luyten, P. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sijens, P. E.
Right arrow Articles by Luyten, P. R.

Radiology, Vol 169, 615-620, Copyright © 1988 by Radiological Society of North America

ARTICLES

Human breast cancer in vivo: H-1 and P-31 MR spectroscopy at 1.5 T

PE Sijens, HK Wijrdeman, MA Moerland, CJ Bakker, JW Vermeulen and PR Luyten
Department of Radiotherapy, University Hospital Utrecht, The Netherlands.

To assess the potential of in vivo magnetic resonance (MR) spectroscopy for breast cancer, hydrogen-1 and phosphorus-31 MR spectra of five malignant human breast tumors were compared with those of unaffected breast tissue. The water-to-fat ratio was high in the tumors (average, 2.2) but low in the unaffected tissue (average, 0.3). The P-31 spectrum of normal breast tissue showed low levels of phosphomonoesters (PMEs), inorganic phosphate, phosphodiesters (PDEs), and ATP. In addition, an intense phosphocreatine (PCr) signal was observed in breast tissue of young women: The relative intensities of the PCr and ATP signals had a mean value of 1.9. The tumor spectrum showed elevated levels of PMEs, Pi, and PDEs, while no PCr was seen (PCr/ATP less than 0.2). In two breast cancers treated with radiation therapy, resulting in a decrease of tumor volume of more than 50%, a similar change in the tumor P-31 spectrum was observed: An intense PCr signal developed (PCr/ATP = 1.1). Control experiments indicated that the appearance of PCr after radiation therapy was the result of a radiation-induced metabolic change in the tumor itself.


This article has been cited by other articles:


Home page
 Am. J. Roentgenol.Home page
G. M. K. Tse, H. S. Cheung, L.-M. Pang, W. C. W. Chu, B. K. B. Law, F. Y. L. Kung, and D. K. W. Yeung
Characterization of Lesions of the Breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
Am. J. Roentgenol., November 1, 2003; 181(5): 1267 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
R. Katz-Brull, P. T. Lavin, and R. E. Lenkinski
Clinical Utility of Proton Magnetic Resonance Spectroscopy in Characterizing Breast Lesions
J Natl Cancer Inst, August 21, 2002; 94(16): 1197 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
D. K. W. Yeung, H. S. Cheung, and G. M. K. Tse
Human Breast Lesions: Characterization with Contrast-enhanced in Vivo Proton MR Spectroscopy—Initial Results
Radiology, July 1, 2001; 220(1): 40 - 46.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1988 by the Radiological Society of North America.