Radiology, Vol 170, 351-356, Copyright © 1989 by Radiological Society of North America

ARTICLES

Acute myocardial ischemia and reperfusion: MR imaging with albumin-Gd- DTPA

U Schmiedl, RE Sievers, RC Brasch, CL Wolfe, WM Chew, MD Ogan, H Engeseth, MJ Lipton and ME Moseley
Contrast Media Laboratory, University of California School of Medicine, San Francisco 94143-0628.

The utility of a macromolecular, intravascular contrast agent, albumin- gadolinium diethylenetriaminepentaacetic acid (DTPA), for the differentiation of acutely ischemic and reperfused myocardium on magnetic resonance (MR) images was investigated. Regional, reversible myocardial ischemia was produced in rats and confirmed. After reperfusion, flow to the compromised myocardial segment returned to baseline. Normal myocardium could not be differentiated from ischemic myocardium on nonenhanced MR images (n = 12). After 5 minutes of myocardial ischemia and after administration of albumin-Gd-DTPA, the ischemic zone involving the free wall of the left ventricle was characterized by the absence of significant enhancement. Normal myocardium appeared homogeneously enhanced (by 145%). This pattern persisted for up to 1 hour of myocardial ischemia. In six rats that underwent myocardial reperfusion after 5 minutes of ischemia, the normal and reperfused myocardium became isointense. Radiotracer studies with albumin-Gd-153-DTPA confirmed the decreased distribution of contrast agent to the ischemic myocardium, possibly due to decreased blood pool or a blocked primary delivery system in the ischemic myocardium.

This article has been cited by other articles:

				S. H. Choi, S. S. Lee, S. I. Choi, S. T. Kim, K. H. Lim, C. H. Lim, H.-J. Weinmann, and T.-H. Lim Occlusive Myocardial Infarction: Investigation of Bis-Gadolinium Mesoporphyrins-enhanced T1-weighted MR Imaging in a Cat Model Radiology, August 1, 2001; 220(2): 436 - 440. [Abstract] [Full Text] [PDF]

				S. I. Choi, S. H. Choi, S. T. Kim, K. H. Lim, C. H. Lim, G. Y. Gong, H. Y. Kim, H.-J. Weinmann, and T.-H. Lim Irreversibly Damaged Myocardium at MR Imaging with a Necrotic Tissue-Specific Contrast Agent in a Cat Model Radiology, June 1, 2000; 215(3): 863 - 868. [Abstract] [Full Text]

				J. Bremerich, M. F. Wendland, H.a. Arheden, R. Wyttenbach, D. W. Gao, J. P. Huberty, M. W. Dae, C. B. Higgins, and M. Saeed Microvascular injury in reperfused infarcted myocardium: noninvasive assessment with contrast-enhanced echoplanar magnetic resonance imaging J. Am. Coll. Cardiol., September 1, 1998; 32(3): 787 - 793. [Abstract] [Full Text] [PDF]

				R. J. Lee, R. E. Sievers, G. J. Gallinghouse, and P. C. Ursell Development of a model of complete heart block in rats J Appl Physiol, August 1, 1998; 85(2): 758 - 763. [Abstract] [Full Text] [PDF]

				T. Simor, W.-J. Chu, L. Johnson, A. Safranko, M. Doyle, G. M. Pohost, and G. A. Elgavish In Vivo MRI Visualization of Acute Myocardial Ischemia and Reperfusion in Ferrets by the Persistent Action of the Contrast Agent Gd(BME-DTTA) Circulation, December 15, 1995; 92(12): 3549 - 3559. [Abstract] [Full Text]

				E. E. van der Wall, H. W. Vliegen, A. de Roos, and A. V.G. Bruschke Magnetic Resonance Imaging in Coronary Artery Disease Circulation, November 1, 1995; 92(9): 2723 - 2739. [Abstract] [Full Text]