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Radiology, Vol 170, 395-399, Copyright © 1989 by Radiological Society of North America

ARTICLES

Mortalities associated with use of a commercial suspension of polyvinyl alcohol

I Repa, GP Moradian, LP Dehner, SM Tadavarthy, DW Hunter, WR Castaneda-Zuniga, GB Wright, H Katkov, P Johnson and B Chrenka
Department of Diagnostic Radiology, University of Minnesota Hospital and Clinic, Minneapolis 55455.

Two cases of symptomatic neonatal hepatic arteriovenous malformation (AVM) are presented. Both were treated with percutaneous transcatheter embolization and a commercially available polyvinyl alcohol suspension. Both infants died soon after AVM embolization. The results of laboratory examination of particle-size homogeneity of this commercial suspension demonstrate marked inhomogeneity of particle size very probably contributed to the death of these patients. A protocol has been developed to help determine appropriate particle size in individual cases; this may help prevent such catastrophic results during transcatheter embolization.


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