Radiology, Vol 180, 147-151, Copyright © 1991 by Radiological Society of North America

ARTICLES

Acute, subacute, and chronic myocardial infarction: quantitative analysis of gadolinium-enhanced MR images

PR van Dijkman, EE van der Wall, A de Roos, NA Matheijssen, AC van Rossum, J Doornbos, A van der Laarse, AE van Voorthuisen and AV Bruschke
Department of Cardiology, University Hospital Leiden, The Netherlands.

The value of gadolinium enhancement to enable detection of infarcted myocardium at T1-weighted magnetic resonance (MR) imaging was assessed in 84 patients after acute myocardial infarction (AMI). Five healthy subjects served as controls. All patients underwent MR imaging before and 20 minutes after administration of gadopentetate dimeglumine. Contrast enhancement of normal myocardium varied 7% +/- 4 after administration of gadopentetate dimeglumine. Mean intensity ratio after gadolinium enhancement in group 1 (imaging less than 1 week after AMI), group 2 (imaging 1-3 weeks after AMI), and group 3 (imaging 3-6 weeks after AMI) was significantly higher than before gadolinium enhancement. In group 4 (imaging more than 6 weeks after AMI), no significant difference was observed. After gadolinium enhancement, the intensity ratio was abnormally increased in 82% of the MR examinations in group 1, in 62% of group 2, in 58% of group 3, and in 12% of group 4. Gadolinium enhancement improved visualization of myocardial infarction at MR imaging up to 6 weeks after onset of symptoms and had a maximal effect within 1 week after AMI.

This article has been cited by other articles:

				H. Mahrholdt, A. Wagner, R.M. Judd, and U. Sechtem Assessment of myocardial viability by cardiovascular magnetic resonance imaging Eur. Heart J., April 2, 2002; 23(8): 602 - 619. [Full Text] [PDF]

				W. G. Rehwald, D. S. Fieno, E.-L. Chen, R. J. Kim, and R. M. Judd Myocardial Magnetic Resonance Imaging Contrast Agent Concentrations After Reversible and Irreversible Ischemic Injury Circulation, January 15, 2002; 105(2): 224 - 229. [Abstract] [Full Text] [PDF]

				S. J. Flacke, S. E. Fischer, and C. H. Lorenz Measurement of the Gadopentetate Dimeglumine Partition Coefficient in Human Myocardium in Vivo: Normal Distribution and Elevation in Acute and Chronic Infarction Radiology, March 1, 2001; 218(3): 703 - 710. [Abstract] [Full Text]

				O. P. Simonetti, R. J. Kim, D. S. Fieno, H. B. Hillenbrand, E. Wu, J. M. Bundy, J. P. Finn, and R. M. Judd An Improved MR Imaging Technique for the Visualization of Myocardial Infarction Radiology, January 1, 2001; 218(1): 215 - 223. [Abstract] [Full Text]

				D. S. Fieno, R. J. Kim, E.-L. Chen, J. W. Lomasney, F. J. Klocke, and R. M. Judd Contrast-enhanced magnetic resonance imaging of myocardium at risk: Distinction between reversible and irreversible injury throughout infarct healing J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1985 - 1991. [Abstract] [Full Text] [PDF]

				R. J. Kim, D. S. Fieno, T. B. Parrish, K. Harris, E.-L. Chen, O. Simonetti, J. Bundy, J. P. Finn, F. J. Klocke, and R. M. Judd Relationship of MRI Delayed Contrast Enhancement to Irreversible Injury, Infarct Age, and Contractile Function Circulation, November 9, 1999; 100(19): 1992 - 2002. [Abstract] [Full Text] [PDF]

				K. Ramani, R. M. Judd, T. A. Holly, T. B. Parrish, V. H. Rigolin, M. A. Parker, C. Callahan, S. W. Fitzgerald, R. O. Bonow, and F. J. Klocke Contrast Magnetic Resonance Imaging in the Assessment of Myocardial Viability in Patients With Stable Coronary Artery Disease and Left Ventricular Dysfunction Circulation, December 15, 1998; 98(24): 2687 - 2694. [Abstract] [Full Text] [PDF]

				E. E. van der Wall, H. W. Vliegen, A. de Roos, and A. V.G. Bruschke Magnetic Resonance Imaging in Coronary Artery Disease Circulation, November 1, 1995; 92(9): 2723 - 2739. [Abstract] [Full Text]