Radiology, Vol 180, 97-99, Copyright © 1991 by Radiological Society of North America
Selective injection of contrast media: inflammatory effects on rabbit fallopian tubes
AS Thurmond, PL Hedgpeth and RM Scanlan
Department of Diagnostic Radiology, Oregon Health Sciences University, Portland 97201.
The inflammatory effects of fallopian tube catheterization and selective
injection of seven contrast agents (ethiodized oil, diatrizoate meglumine
52%, diatrizoate meglumine 66%, iothalamate meglumine 60%, iopamidol,
ioxitol, and ioxaglate) were evaluated in 88 rabbits. The contrast agent
used was randomly selected and selectively injected after unilateral
catheterization; the contralateral side was used for control. Pathologic
inspection of right and left uteri with attached fallopian tubes and
ovaries was done without knowledge of side of catheterization or duration
of time since catheterization. The degree and location of inflammation were
noted. Inflammation disappeared by 4 days in five of seven contrast agents.
Iothalamate meglumine 60% and iopamidol required 2 weeks for disappearance
of inflammation. Essentially no inflammation was associated at any time
with ioxaglate. These findings suggest that all of these contrast agents
would be clinically acceptable for direct injection into the human
fallopian tube.
