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Radiology, Vol 181, 117-120, Copyright © 1991 by Radiological Society of North America

ARTICLES

Hyperintense basal ganglia on T1-weighted MR images in patients receiving parenteral nutrition

SA Mirowitz, TJ Westrich and JD Hirsch
Department of Radiology, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110.

Patterns of intracranial signal intensity on magnetic resonance (MR) images were studied in nine patients undergoing long-term total parenteral nutrition therapy. The duration of therapy ranged from 5 months to 11 years (mean, 5.3 years). Symmetric increased signal intensity on T1-weighted MR images (hyperintense relative to white matter) was observed in the basal ganglia of all patients, without corresponding abnormality on T2-weighted images. Analysis of signal- intensity characteristics and distribution pattern suggests that the basis for these changes may be deposition of intravenously administered paramagnetic trace elements, especially manganese, and/or an astrogliotic reaction to such deposition.


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