Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, L. A.
Right arrow Articles by Brady, R. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, L. A.
Right arrow Articles by Brady, R. O.

Radiology, Vol 182, 451-455, Copyright © 1992 by Radiological Society of North America

ARTICLES

Quantitative chemical shift imaging of vertebral bone marrow in patients with Gaucher disease

LA Johnson, BE Hoppel, EL Gerard, SP Miller, SH Doppelt, GC Zirzow, DI Rosenthal, JM Dambrosia, SC Hill and RO Brady
MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Charlestown 02129.

To evaluate extent of bone marrow involvement and disease severity in Gaucher patients, results of modified Dixon quantitative chemical shift imaging (QCSI) of the lumbar spine were correlated with quantitative analysis of marrow triglycerides and glucocerebrosides and with quantitative determination of splenic volume at magnetic resonance (MR) imaging. High-field-strength MR spectra of surgical marrow specimens were dominated by a single fat and a water peak, validating use of QCSI. QCSI showed average vertebral marrow fat fractions of 10% +/- 8 in Gaucher patients (normal adult averages, 29% +/- 6). Relaxation times for lipid and water approximated normal averages; bulk T1 values were significantly longer, reflecting decreased marrow fat. Glucocerebroside concentrations were higher in Gaucher marrow and inversely correlated with triglyceride concentrations. Extent of marrow infiltration determined by fat fraction measurements correlated with disease severity measured by splenic enlargement. These results show that as Gaucher cells infiltrate bone marrow and displace normal marrow adipocytes, bulk T1 increases due to the higher T1 of water compared with that of fat. QCSI provides a sensitive, noninvasive technique for evaluating bone marrow involvement in Gaucher disease.


This article has been cited by other articles:


Home page
 Am. J. Roentgenol.Home page
R. F. DeMayo, A. H. Haims, M. C. McRae, R. Yang, and P. K. Mistry
Correlation of MRI-Based Bone Marrow Burden Score with Genotype and Spleen Status in Gaucher's Disease
Am. J. Roentgenol., July 1, 2008; 191(1): 115 - 123.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
M. de Fost, J. M.F.G. Aerts, J. E.M. Groener, M. Maas, E. M. Akkerman, M. G. Wiersma, and C. E.M. Hollak
Low frequency maintenance therapy with imiglucerase in adult type I Gaucher disease: a prospective randomized controlled trial
Haematologica, February 1, 2007; 92(2): 215 - 221.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. de Fost, C. E. M. Hollak, J. E. M. Groener, J. M. F. G. Aerts, M. Maas, L. W. Poll, M. G. Wiersma, D. Haussinger, S. Brett, N. Brill, et al.
Superior effects of high-dose enzyme replacement therapy in type 1 Gaucher disease on bone marrow involvement and chitotriosidase levels: a 2-center retrospective analysis
Blood, August 1, 2006; 108(3): 830 - 835.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Maas, C. van Kuijk, J. Stoker, C. E. M. Hollak, E. M. Akkerman, J. F. M. G. Aerts, and G. J. den Heeten
Quantification of Bone Involvement in Gaucher Disease: MR Imaging Bone Marrow Burden Score as an Alternative to Dixon Quantitative Chemical Shift MR Imaging--Initial Experience
Radiology, November 1, 2003; 229(2): 554 - 561.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
G. Mariani, M. Filocamo, F. Giona, G. Villa, A. Amendola, P. Erba, F. Buffoni, F. Copello, A. Pierini, F. Minichilli, et al.
Severity of Bone Marrow Involvement in Patients with Gaucher's Disease Evaluated by Scintigraphy with 99mTc-Sestamibi
J. Nucl. Med., August 1, 2003; 44(8): 1253 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. Maas, C. E. M. Hollak, E. M. Akkerman, J. M. F. G. Aerts, J. Stoker, and G. J. Den Heeten
Quantification of Skeletal Involvement in Adults with Type I Gaucher's Disease: Fat Fraction Measured by Dixon Quantitative Chemical Shift Imaging as a Valid Parameter
Am. J. Roentgenol., October 1, 2002; 179(4): 961 - 965.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
M Maas, L W Poll, and M R Terk
Imaging and quantifying skeletal involvement in Gaucher disease
Br. J. Radiol., May 24, 2002; 75(90001): A13 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
L W Poll, M Maas, M R Terk, M Roca-Espiau, B Bembi, G Ciana, and N J Weinreb
Response of Gaucher bone disease to enzyme replacement therapy
Br. J. Radiol., May 24, 2002; 75(90001): A25 - 36.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
H. J. Mankin, D. I. Rosenthal, and R. Xavier
Gaucher Disease : New Approaches to an Ancient Disease
J. Bone Joint Surg. Am., May 1, 2001; 83(5): 748 - 763.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. Charrow, J. A. Esplin, T. J. Gribble, P. Kaplan, E. H. Kolodny, G. M. Pastores, C. R. Scott, R. S. Wappner, N. J. Weinreb, and J. S. Wisch
Gaucher Disease: Recommendations on Diagnosis, Evaluation, and Monitoring
Arch Intern Med, September 14, 1998; 158(16): 1754 - 1760.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1992 by the Radiological Society of North America.