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Radiology, Vol 183, 65-72, Copyright © 1992 by Radiological Society of North America

ARTICLES

Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging

Y Kawamori, O Matsui, M Kadoya, J Yoshikawa, H Demachi and T Takashima
Department of Radiology, Kanazawa University School of Medicine, Japan.

The potential of superparamagnetic ferrite particles in magnetic resonance (MR) imaging to help differentiate between hyperplastic nodular lesions in the liver and hepatocellular carcinomas was evaluated with chemically induced liver tumors in cirrhotic rats. Ferrite particles decreased the signal intensity of hyperplastic nodules but not that of hepatocellular carcinomas, and stainable iron was found in the former but not in the latter with Prussian blue iron stain. T1-weighted spin-echo images made little contribution to the differentiation between these two lesions, while T2-weighted spin-echo images were effective for this purpose, since ferrite particles cause T2 shortening. Ferrite-enhanced MR imaging may be useful in differentiating these two lesion types according to their signal intensity changes on images, because Kupffer cells are present in hyperplastic nodular lesions but rarely in hepatocellular carcinomas.


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J. H. Lim, D. Choi, S. K. Cho, S. H. Kim, W. J. Lee, H. K. Lim, C. K. Park, S. W. Paik, and Y. I. Kim
Conspicuity of Hepatocellular Nodular Lesions in Cirrhotic Livers at Ferumoxides-enhanced MR Imaging: Importance of Kupffer Cell Number
Radiology, September 1, 2001; 220(3): 669 - 676.
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