Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wahl, R. L.
Right arrow Articles by Ethier, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wahl, R. L.
Right arrow Articles by Ethier, S. P.

Radiology, Vol 183, 643-647, Copyright © 1992 by Radiological Society of North America

ARTICLES

Serum glucose: effects on tumor and normal tissue accumulation of 2-[F- 18]-fluoro-2-deoxy-D-glucose in rodents with mammary carcinoma

RL Wahl, CA Henry and SP Ethier
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028.

The positron-emitter-labeled glucose analogue 2-[fluorine-18]-fluoro-2- deoxy-D-glucose (FDG) accumulates into many cancers after intravenous injection, but the effect of serum glucose levels on FDG uptake in the tumor has not been extensively studied. In vitro, elevated media glucose levels markedly diminished FDG and FDG 6-phosphate uptake and retention in human adenocarcinoma cells, while insulin had no effect. Mammary cancers were established subcutaneously in 12 rats. Six control rats with mammary tumors were fasted overnight. Hyperglycemia was established in six rats by means of continuous glucose infusion (glucose clamp). All animals were then intravenously administered 50 microCi of FDG. Serum glucose levels were 87 mg/dL (4.83 mmol/L) in the control animals and more than 900 mg/dL (49.9 mmol/L) in the hyperglycemic animals. One hour after injection of FDG, mean F-18 uptake in the tumor, brain, small bowel, and ovaries was 2.7-9.7 times lower in the hyperglycemic animals (P less than .02). Mean F-18 activity in the kidneys tended to be somewhat higher in the hyperglycemic animals. FDG uptake in other tissues was comparable between the control and hyperglycemic groups. These data suggest that high serum glucose levels may substantially impair visceral tumor imaging with FDG positron emission tomography.


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
R. Kumar, S. Basu, D. Torigian, V. Anand, H. Zhuang, and A. Alavi
Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of 18F-Fluorodeoxyglucose Positron Emission Tomography
Clin. Microbiol. Rev., January 1, 2008; 21(1): 209 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
S. Assadian, A. Aliaga, R. F. Del Maestro, A. C. Evans, and B. J. Bedell
FDG-PET imaging for the evaluation of antiglioma agents in a rat model
Neuro-oncol, January 1, 2008; 10(3): 292 - 299.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. R. Tseng, K. W. Kang, M. Dandekar, S. Yaghoubi, J. H. Lee, J. G. Christensen, S. Muir, P. W. Vincent, N. R. Michaud, and S. S. Gambhir
Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by 18F-FDG Small-Animal PET
J. Nucl. Med., January 1, 2008; 49(1): 129 - 134.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
M. Dandekar, J. R. Tseng, and S. S. Gambhir
Reproducibility of 18F-FDG microPET Studies in Mouse Tumor Xenografts
J. Nucl. Med., April 1, 2007; 48(4): 602 - 607.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
W. K. Schiffer, M. M. Mirrione, and S. L. Dewey
Optimizing Experimental Protocols for Quantitative Behavioral Imaging with 18F-FDG in Rodents
J. Nucl. Med., February 1, 2007; 48(2): 277 - 287.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. Meller, C.-O. Sahlmann, and A. K. Scheel
18F-FDG PET and PET/CT in Fever of Unknown Origin
J. Nucl. Med., January 1, 2007; 48(1): 35 - 45.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
B. J. Fueger, J. Czernin, I. Hildebrandt, C. Tran, B. S. Halpern, D. Stout, M. E. Phelps, and W. A. Weber
Impact of Animal Handling on the Results of 18F-FDG PET Studies in Mice
J. Nucl. Med., June 1, 2006; 47(6): 999 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
L. K. Shankar, J. M. Hoffman, S. Bacharach, M. M. Graham, J. Karp, A. A. Lammertsma, S. Larson, D. A. Mankoff, B. A. Siegel, A. Van den Abbeele, et al.
Consensus Recommendations for the Use of 18F-FDG PET as an Indicator of Therapeutic Response in Patients in National Cancer Institute Trials
J. Nucl. Med., June 1, 2006; 47(6): 1059 - 1066.
[Full Text] [PDF]

Home page
 JNMHome page
C.-y. O. Wong, J. Thie, K. J. Parling-Lynch, D. Zakalik, J. H. Margolis, M. Gaskill, J. Hill, F. Qing, D. Fink-Bennett, and C. Nagle
Glucose-Normalized Standardized Uptake Value from 18F-FDG PET in Classifying Lymphomas
J. Nucl. Med., October 1, 2005; 46(10): 1659 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T.-C. Yen, K.-K. Ng, S.-Y. Ma, H.-H. Chou, C.-S. Tsai, S. Hsueh, T.-C. Chang, J.-H. Hong, L.-C. See, W.-J. Lin, et al.
Value of Dual-Phase 2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography in Cervical Cancer
J. Clin. Oncol., October 1, 2003; 21(19): 3651 - 3658.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
D. Vranjesevic, C. Schiepers, D. H. Silverman, A. Quon, J. Villalpando, M. Dahlbom, M. E. Phelps, and J. Czernin
Relationship Between 18F-FDG Uptake and Breast Density in Women with Normal Breast Tissue
J. Nucl. Med., August 1, 2003; 44(8): 1238 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
T. Torizuka, T. Kanno, M. Futatsubashi, H. Okada, E. Yoshikawa, F. Nakamura, M. Takekuma, M. Maeda, and Y. Ouchi
Imaging of Gynecologic Tumors: Comparison of 11C-Choline PET with 18F-FDG PET
J. Nucl. Med., July 1, 2003; 44(7): 1051 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
C. J. Hoekstra, O. S. Hoekstra, S. G. Stroobants, J. Vansteenkiste, J. Nuyts, E. F. Smit, M. Boers, J. W.R. Twisk, and A. A. Lammertsma
Methods to Monitor Response to Chemotherapy in Non-Small Cell Lung Cancer with 18F-FDG PET
J. Nucl. Med., October 1, 2002; 43(10): 1304 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Greco, F. Crippa, R. Agresti, E. Seregni, A. Gerali, R. Giovanazzi, A. Micheli, S. Asero, C. Ferraris, M. Gennaro, et al.
Axillary Lymph Node Staging in Breast Cancer by 2-Fluoro-2-deoxy-D-glucose-Positron Emission Tomography: Clinical Evaluation and Alternative Management
J Natl Cancer Inst, April 18, 2001; 93(8): 630 - 635.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
I. C. Smith, A. E. Welch, A. W. Hutcheon, I. D. Miller, S. Payne, F. Chilcott, S. Waikar, T. Whitaker, A. K. Ah-See, O. Eremin, et al.
Positron Emission Tomography Using [18F]-Fluorodeoxy-D-Glucose to Predict the Pathologic Response of Breast Cancer to Primary Chemotherapy
J. Clin. Oncol., April 1, 2000; 18(8): 1676 - 1688.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
Y. Sugawara, K. R. Zasadny, A. W. Neuhoff, and R. L. Wahl
Reevaluation of the Standardized Uptake Value for FDG: Variations with Body Weight and Methods for Correction
Radiology, November 1, 1999; 213(2): 521 - 525.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1992 by the Radiological Society of North America.