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Radiology, Vol 183, 667-672, Copyright © 1992 by Radiological Society of North America

ARTICLES

Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion

Y Berthezene, V Vexler, O Clement, A Muhler, ME Moseley and RC Brasch
Department of Radiology, University of California, San Francisco 94143- 0628.

The use of aerosolized gadopentetate dimeglumine to define regional lung ventilation and of intravenously administered polylysine- (gadopentetate dimeglumine)40 to assess regional lung perfusion was investigated. In 10 healthy rats who breathed aerosolized gadopentetate dimeglumine (0.25 mol/L) for 5 minutes, pulmonary signal intensity increased diffusely in both lungs by more than 70%. When the same animals received intravenously administered polylysine-(gadopentetate dimeglumine)40 (0.1 mmol of gadolinium per kilogram), there was an additional 300% enhancement of the pulmonary parenchyma. In a rat model of acute unilateral pulmonary embolism (n = 5), perfusion defects were identified after administration of polylysine-(gadopentetate dimeglumine)40, but no ventilation abnormality was seen after inhalation of gadopentetate dimeglumine. In a rat model of acute unilateral airway obstruction (n = 5), only the ventilated right lung enhanced after inhalation of gadopentetate dimeglumine. In four of these animals, the focal ventilation defect was accompanied by a matched decrease in perfusion, seen after enhancement of the blood pool with polylysine-(gadopentetate dimeglumine)40.


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