Radiology, Vol 184, 207-213, Copyright © 1992 by Radiological Society of North America
Hepatobiliary enhancement with Gd-EOB-DTPA: comparison of spin-echo and STIR imaging for detection of experimental liver metastases
A Muhler, O Clement, V Vexler, Y Berthezene, W Rosenau and RC Brasch
Department of Radiology, University of California San Francisco 94143- 0628.
Gadolinium (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-
triazaundecandioic acid-disodium salt (EOB-DTPA) ethoxybenzyl is a new
hepatobiliary magnetic resonance (MR) contrast agent with dual elimination:
75% through the liver and bile and 25% through the kidneys in normal rats.
In this study, Gd-EOB-DTPA was evaluated in a rodent model of metastatic
liver disease to measure both relative enhancement and lesion-to-liver
contrast. A secondary goal was to compare the relative performance of
spin-echo (SE) and short inversion time inversion-recovery (STIR) imaging
to demonstrate enhancement with Gd- EOB-DTPA. After administration of 0.1
mmol of Gd-EOB-DTPA per kilogram, liver signal increased (positive
enhancement) more than 200% with the use of the SE technique and declined
(negative enhancement) by more than 80% with use of the STIR technique.
Only minimal enhancement of implanted liver tumor was observed. Unlike the
tumor, the gall-bladder and lumen of the duodenum were progressively
enhanced over time. The lesion-to-liver contrast increased by approximately
500% with both the SE and STIR techniques after administration of
Gd-EOB-DTPA.
