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Radiology, Vol 184, 385-387, Copyright © 1992 by Radiological Society of North America

ARTICLES

Ionic iodinated contrast medium and amobarbital sodium mixtures: potential for precipitation

LH Monsein, TJ Miller, SK Kuwahara, S Sostre and GM Debrun
Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.




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