Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fulham, M. J.
Right arrow Articles by Di Chiro, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fulham, M. J.
Right arrow Articles by Di Chiro, G.

Radiology, Vol 185, 675-686, Copyright © 1992 by Radiological Society of North America

ARTICLES

Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance

MJ Fulham, A Bizzi, MJ Dietz, HH Shih, R Raman, GS Sobering, JA Frank, AJ Dwyer, JR Alger and G Di Chiro
Neuroimaging Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892.

Brain tumor metabolism was studied with hydrogen-1 magnetic resonance spectroscopy and positron emission tomography with fluorine-18 fluorodeoxyglucose in 50 patients. N-acetylaspartate (NAA) was generally decreased in tumors and radiation necrosis but was somewhat preserved at neoplasm margins. Choline was increased in most solid tumors. Solid high-grade gliomas had higher normalized choline values than did solid low-grade gliomas (P < .02), but the normalized choline value was not a discriminator of tumor grade, since necrotic high-grade lesions had reduced choline values. Serial studies in one case showed an increase in choline as the glioma underwent malignant degeneration. Choline values were lower in chronic radiation necrosis than in solid anaplastic tumors (P < .001). In two cases studied before and after treatment, clinical improvement and a reduction in choline followed therapy. Lactate is more likely to be found in high-grade gliomas, but its presence is not a reliable indicator of malignancy.


This article has been cited by other articles:


Home page
 RadiologyHome page
D. A. Hammoud, J. M. Hoffman, and M. G. Pomper
Molecular Neuroimaging: From Conventional to Emerging Techniques
Radiology, October 1, 2007; 245(1): 21 - 42.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. A. Kwee, J. P. Ko, C. S. Jiang, M. R. Watters, and M. N. Coel
Solitary Brain Lesions Enhancing at MR Imaging: Evaluation with Fluorine 18 Fluorocholine PET
Radiology, August 1, 2007; 244(2): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Cianfoni, S. Niku, and S.G. Imbesi
Metabolite Findings in Tumefactive Demyelinating Lesions Utilizing Short Echo Time Proton Magnetic Resonance Spectroscopy
AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 272 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C. Asao, Y. Korogi, M. Kitajima, T. Hirai, Y. Baba, K. Makino, M. Kochi, S. Morishita, and Y. Yamashita
Diffusion-Weighted Imaging of Radiation-Induced Brain Injury for Differentiation from Tumor Recurrence
AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1455 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. L. Zakian, K. Sircar, H. Hricak, H.-N. Chen, A. Shukla-Dave, S. Eberhardt, M. Muruganandham, L. Ebora, M. W. Kattan, V. E. Reuter, et al.
Correlation of Proton MR Spectroscopic Imaging with Gleason Score Based on Step-Section Pathologic Analysis after Radical Prostatectomy
Radiology, March 1, 2005; 234(3): 804 - 814.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. G. Astrakas, D. Zurakowski, A. A. Tzika, M. K. Zarifi, D. C. Anthony, U. De Girolami, N. J. Tarbell, and P. M. Black
Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors
Clin. Cancer Res., December 15, 2004; 10(24): 8220 - 8228.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. A. Herrmann, B. Sporer, and T. A. Yousry
Thrombosis of the Internal Cerebral Vein Associated with Transient Unilateral Thalamic Edema: A Case Report and Review of the Literature
AJNR Am. J. Neuroradiol., September 1, 2004; 25(8): 1351 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
K. E. Warren
NMR Spectroscopy and Pediatric Brain Tumors
Oncologist, June 1, 2004; 9(3): 312 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Law, S. Yang, H. Wang, J. S. Babb, G. Johnson, S. Cha, E. A. Knopp, and D. Zagzag
Glioma Grading: Sensitivity, Specificity, and Predictive Values of Perfusion MR Imaging and Proton MR Spectroscopic Imaging Compared with Conventional MR Imaging
AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 1989 - 1998.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. L. Zakian, S. Eberhardt, H. Hricak, A. Shukla-Dave, S. Kleinman, M. Muruganandham, K. Sircar, M. W. Kattan, V. E. Reuter, P. T. Scardino, et al.
Transition Zone Prostate Cancer: Metabolic Characteristics at H MR Spectroscopic Imaging--Initial Results
Radiology, October 1, 2003; 229(1): 241 - 247.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
P S Murphy, I J Rowland, L Viviers, M Brada, M O Leach, and A S K Dzik-Jurasz
Could assessment of glioma methylene lipid resonance by in vivo 1H-MRS be of clinical value?
Br. J. Radiol., July 1, 2003; 76(907): 459 - 463.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. J. Nelson
Multivoxel Magnetic Resonance Spectroscopy of Brain Tumors
Mol. Cancer Ther., May 1, 2003; 2(5): 497 - 507.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
N. Bulakbasi, M. Kocaoglu, F. Ors, C. Tayfun, and T. Ucoz
Combination of Single-Voxel Proton MR Spectroscopy and Apparent Diffusion Coefficient Calculation in the Evaluation of Common Brain Tumors
AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 225 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. A. Tran, G. N. Fuller, G. J. Whitman, and D. F. Schomer
Radiologic--Pathologic Conferences of the University of Texas M. D. Anderson Cancer Center: Delayed Cerebral Radiation Necrosis
Am. J. Roentgenol., January 1, 2003; 180(1): 70 - 70.
[Full Text] [PDF]

Home page
 RadiologyHome page
J. D. Rabinov, P. L. Lee, F. G. Barker, D. N. Louis, G. R. Harsh, G. R. Cosgrove, E. A. Chiocca, A. F. Thornton, J. S. Loeffler, J. W. Henson, et al.
In Vivo 3-T MR Spectroscopy in the Distinction of Recurrent Glioma versus Radiation Effects: Initial Experience
Radiology, December 1, 2002; 225(3): 871 - 879.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
O. Kizu, K. Yamada, and T. Nishimura
Proton Chemical Shift Imaging in Pick Complex
AJNR Am. J. Neuroradiol., September 1, 2002; 23(8): 1387 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Yang, S. Wetzel, and S. Cha
Dynamic Contrast-Enhanced T2*-Weighted MR Imaging of Gliomatosis Cerebri
AJNR Am. J. Neuroradiol., March 1, 2002; 23(3): 350 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
O. Kizu, K. Yamada, and T. Nishimura
Proton Chemical Shift Imaging in Normal Pressure Hydrocephalus
AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1659 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
F. W. Floeth, A. Aulich, K. J. Langen, K. J. Burger, W. J. Bock, and F. Weber
MR Imaging and Single-Photon Emission CT Findings after Gene Therapy for Human Glioblastoma
AJNR Am. J. Neuroradiol., September 1, 2001; 22(8): 1517 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H.-P. Schlemmer, P. Bachert, K. K. Herfarth, I. Zuna, J. Debus, and G. van Kaick
Proton MR Spectroscopic Evaluation of Suspicious Brain Lesions After Stereotactic Radiotherapy
AJNR Am. J. Neuroradiol., August 1, 2001; 22(7): 1316 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. J. Martin, H. Liu, W. A. Hall, and C. L. Truwit
Preliminary Assessment of Turbo Spectroscopic Imaging for Targeting in Brain Biopsy
AJNR Am. J. Neuroradiol., May 1, 2001; 22(5): 959 - 968.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
C. Dowling, A. W. Bollen, S. M. Noworolski, M. W. McDermott, N. M. Barbaro, M. R. Day, R. G. Henry, S. M. Chang, W. P. Dillon, S. J. Nelson, et al.
Preoperative Proton MR Spectroscopic Imaging of Brain Tumors: Correlation with Histopathologic Analysis of Resection Specimens
AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 604 - 612.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
E. E. Graves, S. J. Nelson, D. B. Vigneron, L. Verhey, M. McDermott, D. Larson, S. Chang, M. D. Prados, and W. P. Dillon
Serial Proton MR Spectroscopic Imaging of Recurrent Malignant Gliomas after Gamma Knife Radiosurgery
AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 613 - 624.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
J. Butzen, R. Prost, V. Chetty, K. Donahue, R. Neppl, W. Bowen, S.-J. Li, V. Haughton, L. Mark, T. Kim, et al.
Discrimination between Neoplastic and Nonneoplastic Brain Lesions by Use of Proton MR Spectroscopy: The Limits of Accuracy with a Logistic Regression Model
AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1213 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H. Shimizu, T. Kumabe, R. Shirane, and T. Yoshimoto
Correlation between Choline Level Measured by Proton MR Spectroscopy and Ki-67 Labeling Index in Gliomas
AJNR Am. J. Neuroradiol., April 1, 2000; 21(4): 659 - 665.
[Abstract] [Full Text]

Home page
 JCOHome page
K. E. Warren, J. A. Frank, J. L. Black, R. S. Hill, J. H. Duyn, A. A. Aikin, B. K. Lewis, P. C. Adamson, and F. M. Balis
Proton Magnetic Resonance Spectroscopic Imaging in Children With Recurrent Primary Brain Tumors
J. Clin. Oncol., March 1, 2000; 18(5): 1020 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
R. G. Henry, D. B. Vigneron, N. J. Fischbein, P. E. Grant, M. R. Day, S. M. Noworolski, J. M. Star-Lack, L. L. Wald, W. P. Dillon, S. M. Chang, et al.
Comparison of Relative Cerebral Blood Volume and Proton Spectroscopy in Patients with Treated Gliomas
AJNR Am. J. Neuroradiol., February 1, 2000; 21(2): 357 - 366.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
P. E. Ricci, A. Pitt, P. J. Keller, S. W. Coons, and J. E. Heiserman
Effect of Voxel Position on Single-Voxel MR Spectroscopy Findings
AJNR Am. J. Neuroradiol., February 1, 2000; 21(2): 367 - 374.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
M. Bendszus, M. Warmuth-Metz, R. Klein, R. Burger, C. Schichor, J. C. Tonn, and L. Solymosi
MR Spectroscopy in Gliomatosis Cerebri
AJNR Am. J. Neuroradiol., February 1, 2000; 21(2): 375 - 380.
[Abstract] [Full Text]

Home page
 RadiologyHome page
A. R. Margulis and J. H. Sunshine
Radiology at the Turn of the Millennium1
Radiology, January 1, 2000; 214(1): 15 - 23.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
M. E. Meyerand, J. M. Pipas, A. Mamourian, T. D. Tosteson, and J. F. Dunn
Classification of Biopsy-Confirmed Brain Tumors Using Single-Voxel MR Spectroscopy
AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 117 - 123.
[Abstract] [Full Text]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G Tedeschi, S Bonavita, N W Barton, A Bertolino, J A Frank, N J Patronas, J R Alger, and R Schiffmann
Proton magnetic resonance spectroscopic imaging in the clinical evaluation of patients with Niemann-Pick type C disease
J. Neurol. Neurosurg. Psychiatry, July 1, 1998; 65(1): 72 - 79.
[Abstract] [Full Text]

Home page
 RadiologyHome page
M. Law, S. Cha, E. A. Knopp, G. Johnson, J. Arnett, and A. W. Litt
High-Grade Gliomas and Solitary Metastases: Differentiation by Using Perfusion and Proton Spectroscopic MR Imaging
Radiology, March 1, 2002; 222(3): 715 - 721.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1992 by the Radiological Society of North America.